Preheat the oven to 350°F. Grease an 11 x 7-inch baking dish with nonstick cooking spray; set aside.
2 cups uncooked medium shells pasta
Cook the pasta in a large pot of salted boiling water according to package directions for al dente. Drain.
Meanwhile, cook the ground beef in a Dutch oven or large, deep skillet over medium heat until no longer pink. Drain off the excess grease. Add the chili powder, paprika, garlic powder, and onion powder. Stir until it's warmed through and completely combined with the meat, about 30 seconds.
1 lb. lean ground beef
Stir in the salsa, condesned soup, and Velveeta cheese. Cook, stirring, over medium heat until the cheese melts smoothly into the sauce.
1 (16 ounce) jar of "thick and chunky" salsa, 1 (10.5 ounce) can condensed cream of chicken soup, 8 ounces Velveeta cheese,
Add the cooked pasta to the meat mixture; stir to combine.
Transfer the beef and pasta mixture to the prepared baking dish.
Sprinkle the shredded Mexican cheese on top. Cover with foil.
1 cup shredded Mexican cheese blend
Bake for about 20 minutes, or until the cheese is melted and the filling is hot and bubbly.
Garnish with optional cilantro or green onions and serve immediately.