Preheat the oven to 425°F (220°C). Spray a deep 9 x 13-inch baking dish with nonstick cooking spray. Set aside.
In a small bowl, stir together the cottage cheese, Parmesan cheese, egg, parsley, ¼ teaspoon of salt, garlic powder, and pepper. Set aside.
In a separate bowl, whisk together the marinara sauce, water, Italian seasoning, and remaining ½ teaspoon of salt. Set aside.
Spread about half of the uncooked pasta in the bottom of the prepared dish. Pour about half of the sauce mixture over top.
Dollop the cottage cheese mixture over the pasta.
Top with another layer of the remaining uncooked pasta and the remaining sauce mixture.
Cover tightly with aluminum foil and bake for 40 minutes.
Uncover. At this point you should check the pasta to make sure that it is al dente (firm but just about finished cooking; it doesn't need to be completely done yet). If it’s still really hard, cover the dish and return it to the oven until the pasta is al dente. Then move on to the next step.
Sprinkle the mozzarella over the top.
Bake uncovered until the cheese melts and the pasta is tender, about 5-10 more minutes.