Preheat oven to 375°F. Line a rimmed baking sheet with parchment paper and set aside.
In a small bowl, stir together ketchup and Worcestershire sauce. Set aside.
In a large bowl, use your hands or a fork to gently combine beef, pork, cornbread crumbs, onion, eggs, basil, Dijon, garlic, salt, oregano, pepper, and ½ cup of the ketchup mixture. Mix until just combined. Be careful not to overmix or the meatloaf will be dense.
On the prepared baking sheet, shape the meat mixture into a rectangular loaf.
Spread the remaining ketchup mixture evenly over the top.
Bake for about 1 hour, until the internal temperature reaches 160°F and the meatloaf is cooked through.
Remove from the oven and let rest for 5-10 minutes before slicing. Serve warm with mashed potatoes and fresh herbs if desired.