Preheat oven to 425°F. Grease a 13 x 9-inch baking dish or spray with nonstick cooking spray.
In the prepared dish (or in a separate bowl), stir together the stir together frozen tortellini, frozen meatballs, marinara sauce, water, red wine, Italian seasoning, red pepper flakes, garlic powder, and onion powder. Season with a little bit of salt to taste; stir. Cover tightly with aluminum foil and bake for 30 minutes.
Remove dish from oven; stir well. At this point, the pasta should be tender and the meatballs should be warm. If the tortellini or meatballs are still undercooked, cover the dish and return to the oven until done. Then move on to the next step.
Heat the broiler on HIGH. Sprinkle mozzarella and Parmesan over the top of the casserole. Place the dish (uncovered) under the broiler for a couple of minutes, just until the cheese melts. Keep a close eye on the dish while it’s under the broiler, since it can burn quickly.