In a small bowl, combine paprika, chili powder, kosher salt, cumin, oregano, onion powder, garlic powder, and cayenne. Set the seasoning mix aside.
In a medium bowl, combine shrimp, 1 tablespoon of oil, and about half of the seasoning mix.
In a large cast iron skillet, heat remaining 1 tablespoon of oil over medium-high heat. Add bell peppers and onion. Cook, stirring occasionally, until vegetables are browned and tender, about 10-12 minutes. Stir in remaining half of the seasoning mix. Remove pepper mixture from the skillet.
In the same skillet, cook the shrimp over medium-high heat until pink and firm, about 2-3 minutes per side. Return the pepper mixture to the skillet; stir to combine.
Squeeze the lime juice over top. Taste and season with additional salt and pepper, if necessary.
Serve shrimp mixture alongside rice, over salad, or tucked in flour tortillas with your favorite toppings.