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Roasted Butternut Squash Lasagna

This cheesy, flavorful, butternut squash lasagna with spinach, mushrooms, onions, and three different types of cheese is the essence of fall!
Course Dinner
Cuisine American, Italian
Keyword butternut squash lasagna, vegetarian lasagna, vegetarian thanksgiving recipes
Prep Time 1 hour 30 minutes
Cook Time 40 minutes
Resting Time 15 minutes
Total Time 2 hours 25 minutes
Servings 8 people
Calories 417kcal
Author Blair Lonergan

Ingredients

FOR THE BUTTERNUT SQUASH LAYER:

  • 1 (large) butternut squash (about 3 ½ - 4 pounds)
  • 1-2 tablespoons olive oil
  • cup milk
  • 1 teaspoon fresh thyme leaves (or ½ teaspoon dried thyme leaves)
  • 2 fresh sage leaves (or ¼ teaspoon dried sage)
  • ¾ teaspoon kosher salt
  • Dash of ground black pepper

FOR THE MUSHROOM LAYER:

  • ¼ cup (½ of a stick) salted butter
  • 2 large yellow onions, thinly sliced
  • 8 ounces sliced baby bella mushrooms or white button mushrooms
  • ½ teaspoon chopped fresh thyme leaves (or ¼ teaspoon dried thyme)
  • 1 fresh sage leaf chopped (or ⅛ teaspoon dried sage)
  • Kosher salt and ground black pepper, to taste

FOR THE RICOTTA SPINACH LAYER:

  • 1 (10 ounce) package frozen chopped spinach, thawed
  • 15 ounces ricotta cheese (or sub with 16 ounces small curd cottage cheese, extra liquid strained)
  • 1 cup shredded mozzarella cheese
  • ¼ cup grated Parmesan cheese
  • 1 large egg, lightly beaten
  • ½ teaspoon salt
  • ½ teaspoon garlic powder
  • teaspoon ground nutmeg

FOR ASSEMBLING:

  • 1 (12 ounce) package no-boil (“oven ready”) lasagna noodles (you probably will not need the entire box; I use 10 noodles total)
  • 1 ½ cups shredded mozzarella cheese
  • ¼ cup grated Parmesan cheese
  • Optional garnish: chopped fresh parsley or other herbs

Instructions

  • Preheat oven to 400°F. Grease a deep 13 x 9-inch baking dish; set aside.

PREPARE THE BUTTERNUT SQUASH:

  • Slice squash vertically down the center, and scoop out the seeds. Rub olive oil all over the squash, and place the halves cut-side down on a baking sheet lined with parchment paper. Roast in the oven for about 50-60 minutes, or until very tender.
  • Allow squash to cool, peel the skin off, and transfer the flesh to a food processor or blender.
  • Add the milk, thyme, sage, salt, and pepper. Blend until smooth; set aside.

PREPARE THE MUSHROOMS:

  • Melt the butter in a large skillet over medium-high heat. Add the onions and saute until soft, about 8 minutes. Increase the heat to high, add the mushrooms, thyme, and sage, and cook until tender, about 3 more minutes. Remove from the heat. Season with salt and pepper to taste. Set aside.

PREPARE THE RICOTTA SPINACH LAYER:

  • Squeeze all of the liquid out of the spinach. I like to use a dish towel for this, and just keep squeezing until you wring out as much water as possible. Place spinach in a large bowl.
  • Add ricotta, mozzarella, Parmesan, egg, salt, garlic powder, and nutmeg to the bowl with the spinach. Stir really well with a fork to combine.

ASSEMBLE THE LASAGNA:

  • Spread about ¾ cup of the butternut squash mixture on the bottom of the prepared baking dish. Top with a layer of no-boil lasagna noodles (using as many as you need to cover a single layer in the dish), ½ of the ricotta mixture, and ½ of the mushroom mixture.
  • Add a heaping 1 cup of the butternut squash mixture on top, another layer of noodles, the remaining ricotta mixture, and the remaining mushrooms.
  • Spread any remaining butternut squash on top. Finish with 1 ½ cups of shredded mozzarella cheese and ¼ cup of grated Parmesan cheese.
  • Cover the dish with foil.
  • Bake for 25 minutes. Remove the cover and bake for about 15 more minutes, until the filing is hot and bubbly and the cheese on top is nicely browned.
  • Let stand for at least 15 minutes before slicing and serving. Garnish with additional chopped fresh herbs, if desired.

Nutrition

Serving: 1slice | Calories: 417kcal | Carbohydrates: 26g | Protein: 22g | Fat: 26g | Saturated Fat: 14g | Polyunsaturated Fat: 1g | Monounsaturated Fat: 8g | Trans Fat: 0.3g | Cholesterol: 108mg | Sodium: 828mg | Potassium: 443mg | Fiber: 3g | Sugar: 4g | Vitamin A: 4941IU | Vitamin C: 5mg | Calcium: 425mg | Iron: 1mg